Substrate: Carboxy terminus of Hsp70-interacting protein (Enzyme: Ligase)
Seq-ID: Q9UNE7 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48435   M3K3_HUMAN
MINT-48665   NFKB1_HUMAN
MINT-48831   M3K14_HUMAN
MINT-65548   EM55_HUMAN
MINT-65549   KHDR1_HUMAN
MINT-1785958   HSF1_HUMAN
MINT-1786001   HS90B_HUMAN
MINT-1786017   HSP7C_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Hsp90 protein binding,
ubiquitin-ubiquitin ligase activity,
protein homodimerization activity,
TPR domain binding,
protein binding, bridging,
SMAD binding,
kinase binding,
misfolded protein binding,
Hsp70 protein binding		 cytoplasm,
ubiquitin conjugating enzyme complex,
nuclear inclusion body,
ubiquitin ligase complex		 ubiquitin-dependent SMAD protein catabolic process,
positive regulation of cellular chaperone-mediated protein complex assembly,
protein autoubiquitination,
protein maturation,
proteasomal ubiquitin-dependent protein catabolic process,
positive regulation of protein ubiquitination,
regulation of glucocorticoid metabolic process,
cellular response to misfolded protein,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
protein polyubiquitination,
misfolded or incompletely synthesized protein catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 19 GGARLGAGGGSPEKSPSAQEL - 15302935
HTP
0.14
 - -
0.71
 --
S 19 GGARLGAGGGSPEKSPSAQEL - 17081983
HTP
0.14
 - -
0.71
 --
S 19 GGARLGAGGGSPEKSPSAQEL - 16964243
HTP
0.14
 - -
0.71
 --
S 19 GGARLGAGGGSPEKSPSAQEL - 17287340
HTP
0.14
 - -
0.71
 --
S 19 GGARLGAGGGSPEKSPSAQEL - 18669648
HTP
0.14
 - -
0.71
 --
S 23 LGAGGGSPEKSPSAQELKEQG - 15302935
HTP
0.11
 - -
0.72
 --
S 23 LGAGGGSPEKSPSAQELKEQG - 17081983
HTP
0.11
 - -
0.72
 --
S 23 LGAGGGSPEKSPSAQELKEQG - 16964243
HTP
0.11
 - -
0.72
 --
S 23 LGAGGGSPEKSPSAQELKEQG - 18669648
HTP
0.11
 - -
0.72
 --
S 273 RVGHFDPVTRSPLTQEQLIPN - 18669648
HTP
0.06
 - Ubox
0.48
 2C2V 37.70%
T 276 HFDPVTRSPLTQEQLIPNLAM - 17525332
HTP
0.30
 - Ubox
0.47
 2C2V 16.44%

Substrate: Carboxy terminus of Hsp70-interacting protein (Enzyme: Ligase)
Seq-ID: Q9WUD1 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Hsp90 protein binding,
ubiquitin-ubiquitin ligase activity,
protein homodimerization activity,
TPR domain binding,
protein binding, bridging,
SMAD binding,
Hsp70 protein binding		 cytoplasm,
ubiquitin conjugating enzyme complex,
ubiquitin ligase complex		 ubiquitin-dependent SMAD protein catabolic process,
protein autoubiquitination,
protein folding,
protein maturation,
proteasomal ubiquitin-dependent protein catabolic process,
positive regulation of protein ubiquitination,
regulation of glucocorticoid metabolic process,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
protein polyubiquitination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 20 GARLGTGGGGSPDKSPSAQEL - 16452087
HTP
0.14
 - -
0.75
 --
S 20 GARLGTGGGGSPDKSPSAQEL - 17242355
HTP
0.14
 - -
0.75
 --
S 20 GARLGTGGGGSPDKSPSAQEL - 19144319
HTP
0.14
 - -
0.75
 --

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